hemocell
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Variables
Cell mechanics constants

Variables

constexpr T MaxCellVolumetricChange = 0.01
 The maximum volumetric change of an cell to maintain quasi-incompressibility.
 
constexpr T MaxCellSurfaceAreaChange = 0.09
 The maximum change of the cells surface area is limited to 30%.
 
constexpr T MaxCellBendingAngle = 0.0555
 The maximum bending angle for red/white blood cells. The bending angle of the RBC/WBC are changed to allow for increased stability when encountering high shear flows during the simulations.
 
constexpr T MaxPLTBendingAngle = 2.467
 The maximum bending angle for platelets. Approximately (pi/2)^2 as derived from the smallest representable curvature of the triangulated surface mesh.
 
constexpr T MaxCellPersistenceLength = 9.0
 The maximum link force derived from persistence lengths. This maximum cell persistence length allows for at most 300% stretching.
 

Detailed Description

A set of constants defining the cell stiffness for various deformation modes. The presentation and derivation of these constants are presented in the validation paper: https://doi.org/10.3389/fphys.2017.00563.

Note that these parameters are not unique, i.e. multiple combinations of the constants can result in validated cell behaviour.

The current set of parameters is slightly different as presented in the original publication, specifically MaxCellBendingAngle has been reduced to achieve improved stability when RBCs are subjected to high shear flows. Although this results in slightly stiffer cell mechanics, the obtained force-displacement curves are still within the range of the validation data. For reference, please refer to examples/stretchCell.

All parameters are expressed as their squared value to prevent computation of the square at each evaluation.

Variable Documentation

◆ MaxCellBendingAngle

constexpr T MaxCellBendingAngle = 0.0555
constexpr

The maximum bending angle for red/white blood cells. The bending angle of the RBC/WBC are changed to allow for increased stability when encountering high shear flows during the simulations.

◆ MaxCellPersistenceLength

constexpr T MaxCellPersistenceLength = 9.0
constexpr

The maximum link force derived from persistence lengths. This maximum cell persistence length allows for at most 300% stretching.

◆ MaxCellSurfaceAreaChange

constexpr T MaxCellSurfaceAreaChange = 0.09
constexpr

The maximum change of the cells surface area is limited to 30%.

◆ MaxCellVolumetricChange

constexpr T MaxCellVolumetricChange = 0.01
constexpr

The maximum volumetric change of an cell to maintain quasi-incompressibility.

◆ MaxPLTBendingAngle

constexpr T MaxPLTBendingAngle = 2.467
constexpr

The maximum bending angle for platelets. Approximately (pi/2)^2 as derived from the smallest representable curvature of the triangulated surface mesh.